Somatic Variant Calling with Mutect2 - GATK Best Practices Tutorial
Save Big on Coursera Plus. 7,000+ courses at $160 off. Limited Time Only! Grab it Dive into a comprehensive 38-minute tutorial on somatic variant calling using Mutect2, following GATK's best practices. Explore the differences between germline and somatic variants, understand the challenges in somatic variant calling, and learn about the workflow's key components. Gain insights into germline filtering, Panel of Normals (PoN), contamination estimation, and read orientation bias. Discover the applications of somatic variants in research and familiarize yourself with relevant databases. Follow along with a hands-on demonstration covering data preparation, variant calling with Mutect2, contamination estimation, artifact detection, variant filtering, and annotation using Funcotator. Access provided code repositories and related tutorials to enhance your understanding of bioinformatics techniques in genomic analysis.