Explore molecular techniques used in cancer diagnosis across cellular pathology subspecialties in this comprehensive talk. Learn about immunohistochemistry, methylation profiling, fluorescence in situ hybridisation (FISH), and various sequencing modalities. Discover the advantages of each technique for pathologists in accurately characterizing tumors and identifying patients suitable for targeted therapies. Delve into topics such as tissue assessment, DNA mutations, DNA methylation in neuropathology, challenges in methylation profiling, DNA copy number interpretation, fusion translocations, and sequencing examples in sarcomas and brain tumors. Gain insights into improved diagnostic methods and their applications in different cancer types.