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Intro

Sudden Cardiac Death and Out-of-Hospital Cardiac Arrest

Racial and Sex Differences in Sudden Cardiac Death: The REGARDS Study

Lifetime Cumulative Incidence of SCD in ARIC by Race and Sex groups

Causes of Sudden Cardiac Death

Prospective Autopsy Characterization of Sudden Cardiac Death in San Francisco County: POST SCD Study

Mechanism of Sudden Cardiac Death

Proportion of EMS treated Cardiac Arrests with VF as Initial Rhythm in Seattle, USA

Treatment: Cardiopulmonary Resuscitation and Defibrillation

First Documented Cardiac Rhythm in Witnessed Arrests/ROC Epistry-Cardiac Arrest

Future Approaches to Resuscitation

Current Approach to SCD Prevention

Primary Prevention of SCD: ICD Trials

Wearable Defibrillator after Acute MI: The VEST Trial

LV Dysfunction and ICD Utilization after MI:Pre-SCD II Registry

Paradigm HF

LVEF and SCD Implications for Prevention and ICD Utilization

Estimating Myocardial Infarction Size With a Simple Electrocardiographic Marker Score

Arrhythmic Sudden Death Survival Prediction using Deep Learning Analysis of MRI SCAR in CHD

Biomarkers and SCD in the General Population

Replication of Biomarkers in the Population: Harvard SCD Consortium

Additive Value of Biomarkers on SCD Risk

Familial Aggregation of SCD

GWAS of Sudden Cardiac Arrest in General Population

Genetic Risk Scores and Sudden Cardiac Arrest: Mendelian Randomization

Rare Sequence Variation and SCD Exome Sequencing

Characteristics of SCD cases and controls

Filtration and Classification of Variants identified by Exome Sequencing

Pathogenic or Likely Pathogenic Variants in MESA Population

ECG Measures and SCD Risk General Population Studies

Absolute Incidence of SCD across High and Low Risk Populations

SCD Prevention in General Populations: Healthy Lifestyle and SCD

Sudden Death in HFPEF - TOPCAT Trial

PRE-DETERMINE Cohort Study (R01HL091069)SCD Risk Prediction in Patients without Severe Systolic Dysfunction

PREDETERMINE Baseline Characteristics

LVEF and Mode of Death in PRE-DETERMINE

Differential Association of Clinical Risk Factors With Sudden and/or Arrhythmic Death (SAD) vs. Competing Modes of Death

Age and Risk of Sudden and/or Arrhythmic Death (SAD) vs. Competing Modes of Death

Potential Impact of Absolute Risk on ICD Benefit: Number Needed to Treat (NNT) to Save One Life

Competing Risks and ICD Benefit: Proportional SAD Risk and Percent Mortality Reduction

DANISH TRIAL: IMPACT OF AGE ON COMPETING RISK

Importance of Competing Risk in Selecting Candidates for ICD Therapy

The ECG Stratifies SCD in Coronary Heart Disease Patients PREDETERMINE and ARTEMIS

Polygenic Risk Score (PRS) for CAD Specifically Predicts SAD in PREDETERMINE

Polygenic Risk Score (PRS): Additive SAD Risk Prediction to Clinical Factors and ECG

Summary: Challenges to Reducing Mortality from Sudden Cardiac Death

The Next Frontier: Moving Beyond the Low LVEF Population

Description:

Explore a comprehensive 59-minute grand rounds lecture on predicting and preventing sudden cardiac death in patients without systolic dysfunction. Delve into current challenges in sudden cardiac death prevention, potential future solutions, and the importance of considering competing risks in risk stratification. Examine racial and sex differences in sudden cardiac death incidence, causes, and mechanisms. Learn about primary prevention strategies, including ICD trials and wearable defibrillators. Investigate biomarkers, genetic factors, and ECG measures for risk assessment in general populations. Analyze the PRE-DETERMINE cohort study and its findings on risk prediction in patients without severe systolic dysfunction. Understand the impact of age and competing risks on ICD benefit and patient selection. Discover how ECG and polygenic risk scores can enhance risk stratification in coronary heart disease patients. Gain insights into the challenges and future directions for reducing sudden cardiac death mortality beyond low LVEF populations. Read more

Predicting and Preventing Sudden Cardiac Death in Patients Without Systolic Dysfunction

Cardiology University of Washington

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#Health & Medicine #Health Care #Cardiology #Heart Failure #Arrhythmias #Science #Medicine #Medical Research #Biomarkers #Biology #Electrocardiography

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