Explore how cells divide labor using communication and spatial cues in this 33-minute Medical and Population Genetics Primer lecture from the Broad Institute. Delve into the mechanisms of tissue division of labor regulated by superimposed signals and cell-cell interactions. Examine the specialization of intestinal enterocytes affected by oxygen gradients along the intestinal villus. Investigate optimal task allocation models for cells using cell-cell interactions to regulate performance. Analyze how these interactions lead to diverse patterns in gene expression and tissue space. Study the fibroblast population to test theoretical predictions, exploring potential cross-talk between colon fibroblast archetypes. Learn how fibroblasts potentially use lateral inhibition to divide labor and how archetype crosstalk networks can be used to dissect communication-driven tissue organization in the absence of spatial information.