Explore profiler-guided optimization techniques in this 38-minute conference talk presented by Evan Weinberg from NVIDIA at IPAM's workshop for Co-design for the Exascale and IPAM Hackathon. Gain insights into the SNAP (Synthetic Neutral Atom Potential) application and learn how profiling tools can be leveraged to enhance performance in high-performance computing environments. Discover strategies for identifying bottlenecks, optimizing code, and improving overall efficiency in exascale computing applications. Recorded on May 23, 2023, this presentation offers valuable knowledge for researchers, developers, and professionals working on cutting-edge computational challenges at the Institute for Pure & Applied Mathematics (IPAM) at UCLA.