95 - Robustness in Biological Systems: Organising Principles
10
94 - Robustness in Biological Systems: Mechanisms
11
93 - Robustness in Biological Systems
12
92 - Computational Modelling of Host--Pathogen Interactions
13
91 - Computational Modelling of Host--Pathogen Interactions
14
90 - Lab: Modelling Gene Regulatory Networks
15
89 - Lab: Modelling Gene Regulatory Networks
16
88 - Modelling Gene Regulatory Networks
17
87 - Modelling Gene Regulatory Networks
18
86 - Modelling Gene Regulatory Networks
19
85 - Lab: $^{13}$C-Metabolic Flux Analysis using Mass Spectrometry
20
84 - $^{13}$C-Metabolic Flux Analysis using Mass Spectrometry
21
83 - $^{13}$C-Metabolic Flux Analysis using Mass Spectrometry
22
82 - $^{13}$C-Metabolic Flux Analysis using Mass Spectrometry
23
81 - Constraint-based Modelling of Metabolic Networks: Recap
24
80 - Constraint-based Modelling of Metabolic Networks: Recap
25
79 - Constraint-based Modelling of Metabolic Networks: Recap
26
78 - Lab: Gene Deletions
27
77 - Constraint-based Modelling of Metabolic Networks: Applications
28
76 - Constraint-based Modelling of Metabolic Networks: Applications
29
75 -Constraint-based Modelling of Metabolic Networks: Applications
30
74 - Elementary Modes
31
73 - Elementary Modes
32
72 -Integrating Regulatory Information into Constraint-Based Models
33
71 - Lab: Gene Deletions
34
70 - Constraint-based Modelling of Metabolic Networks
35
69 - Perturbations to Metabolic Networks: Synthetic Lethals
36
68 - Perturbations to Metabolic Networks: Synthetic Lethals
37
67 - Perturbations to Metabolic Networks: Over-expression
38
66 - Understanding FBA
39
65 - Understanding FBA
40
64 - Lab: COBRA Toolbox
41
63 - Perturbations to Metabolic Networks: Deletions
42
62 - Lab: FBA using MATLAB
43
61 - Other Constraint-Based Approaches
44
60 - Other Constraint-Based Approaches
45
59 - Flux Balance Analysis
46
58 - Flux Balance Analysis
47
57 - Flux Balance Analysis
48
56 - Constraint-based Modelling of Metabolic Networks
49
55 - Guest Lecture: Quantitative Systems Pharmacology
50
54 - Guest Lecture: Quantitative Systems Pharmacology
51
53 - Guest Lecture: Quantitative Systems Pharmacology
52
52 - Guest Lecture: Modelling in Drug Development
53
51 - Guest Lecture: Modelling in Drug Development
54
50 - Lab: Parameter Estimation
55
49 - Dynamic Modelling Recap
56
48 - PyGMO
57
47 - Other Evolutionary Algorithms
58
46 - Genetic Algorithms
59
45 - Genetic Algorithms
60
44 - Direct Search Methods
61
43 - Methods for Parameter Estimation
62
42 - Parameter Estimation
63
41 - Parameter Estimation
64
40 - Parameter Estimation
65
39 - Lab: Example Biological Model
66
38 - Lab: Solving ODEs in MATLAB
67
37 - Introduction to Dynamic Modelling
68
36 - Introduction to Dynamic Modelling
69
35 - Introduction to Dynamic Modelling
70
34 - Reconstruction of Signalling Networks
71
33 - Reconstruction of Signalling Networks
72
32 - Reconstruction of Protein Networks
73
31 - Reconstruction of Gene Regulatory Networks
74
30 - Lab: Network Models & Perturbations
75
29 - Lab: Network Models & Perturbations
76
28 - Network Biology: Recap
77
27 - Lab: Network Biology
78
26 - Lab: Cytoscape
79
25 - Lab: Cytoscape
80
24 - Network Motifs
81
23 - Community Detection
82
22 - Network Perturbations
83
21 - Biological Networks
84
20 - Network Models
85
19 - Network Models
86
18 - Network Biology
87
17 - Introduction to Network Biology
88
16 - Introduction to Network Biology
89
15 - Introduction to Network Biology
90
14 - Introduction to Networks
91
13 - Introduction to Networks
92
12 - Lab: MATLAB Basics
93
11 - Lab: MATLAB Basics
94
10 - Lab: MATLAB Basics
95
09 - Lab: MATLAB Basics
96
08 - Representation of Biological Networks
97
07 - Some Example Models
98
06 - Fundamentals of Mathematical Modelling
99
05 - Fundamentals of Mathematical Modelling
100
04 - Fundamentals of Mathematical Modelling
101
03 - Introduction to Modelling
102
02 - Introduction to Modelling
103
01 - Introduction
Description:
COURSE OUTLINE: Every living cell is the result of beautifully concerted interplay of metabolic, signalling and regulatory networks. Systems biology has heralded a systematic quantitative approach to study these complex networks, to understand, predict and manipulate biological systems. Systems biology has had a positive impact on metabolic engineering as well as the pharmaceutical industry. This course seeks to introduce key concepts of mathematical modelling, in the context of different types of biological networks. The course will cover important concepts from network biology, modelling of dynamic systems and parameter estimation, as well as constraint-based metabolic modeling. Finally, we will also touch upon some of the cutting-edge topics in the field. The course has a significant hands-on component, emphasizing various software tools and computational methods for systems biology