Explore the final installment of a five-part lecture series on the pharmacokinetics and pharmacodynamics of therapeutic proteins, presented by Dr. Bernd Meibohm as part of the NIH Principles of Clinical Pharmacology Course. Delve into the crucial topic of immunogenicity and its impact on therapeutic protein efficacy. Examine the various factors that modulate immunogenicity and understand the roles of antidrug antibodies, immune complexes, clearing antibodies, and sustaining antibodies. Conclude with a comprehensive summary, test your knowledge with a self-assessment question, and access recommended further reading materials. Gain valuable insights into this essential aspect of clinical pharmacology, enhancing your understanding of rational drug development and therapeutic utilization.