Explore the latest advancements in universal influenza vaccine development through this informative lecture from the NIH Clinical and Translational Research Summer Course. Delve into the challenges posed by influenza diversity and constant mutations, and discover how ferritin nanoparticles are being engineered as a self-assembling vaccine platform. Learn about the protective capabilities of H1N1 HA stem nanoparticles against lethal H5N1 challenges and the stabilization of Group 2 HA stem for heterosubtypic influenza protection. Examine the development of a computationally designed two-component nanoparticle platform and the effectiveness of mosaic nanoparticle vaccines against divergent H1N1 and H3N2 strains, as well as heterosubtypic H5N1 and H7N9 strains. Gain insights into potential career opportunities at the NIH and the unique resources available for clinical and translational research.