Explore pharmacokinetic concepts in this comprehensive lecture from the NIH Principles of Clinical Pharmacology Course. Delve into the fundamentals of clinical pharmacology, focusing on rational drug development and therapeutic utilization. Learn about dose-response relationships, therapeutic drug monitoring, and target concentration strategies. Examine distribution volumes, elimination half-life, and maintenance therapy using digoxin as a case study. Understand creatinine clearance equations and their importance in drug dosing. Investigate steady-state concentrations and the complexities of phenytoin kinetics. Gain insights into apparent first-order kinetics and their clinical implications. This 54-minute presentation by Dr. Juan J.L. Lertora offers a deep dive into essential pharmacokinetic principles for healthcare professionals and researchers in the field of clinical pharmacology.