Explore the intricacies of therapeutic protein pharmacology in this 24-minute lecture, part of the NIH Principles of Clinical Pharmacology Course. Delve into protein degradation, drug disposition, and dose-dependent clearance mechanisms. Examine glomerular filtration and protein metabolism, with a focus on renal and hepatic impairment impacts. Gain valuable insights into the complexities of pharmacokinetics and pharmacodynamics of therapeutic proteins, essential for rational drug development and utilization in therapeutics. For further information or questions about the course, contact the coordinator at [email protected].