Explore a 39-minute lecture from the Medical and Population Genetics Primer series at the Broad Institute, focusing on individual-level tissue-specific imputed transcriptomes in drug target prioritization and disease risk prediction. Delve into complex trait genetics, covering topics such as trait-relevant tissues, transcriptome imputation, druggable gene prioritization, and gene expression-based risk prediction. Learn about the joint analysis of Transcriptome-Wide Association Studies (TWAS) and co-localization, as well as Polygenic Risk Scores and their applications in risk discrimination and group stratification. Gain insights into phenome-wide scans for established drug targets and understand the key takeaways from this comprehensive overview of cutting-edge genetic research techniques.