Explore the critical aspects of toxicology in emergency medicine through this comprehensive lecture from The National Emergency Medicine Board Review Course. Delve into the principles of toxicology, focusing on essential knowledge for board exams and practical clinical applications. Learn about decontamination techniques, antidotes, and drug elimination methods. Examine the significance of hypokalemia in drug overdoses and understand the contraindications of various treatments. Analyze the effectiveness of toxicology screens, interpret drug levels, and recognize false positives. Gain insights into the increased osmolar gap and its implications in toxicology cases. This focused presentation equips emergency physicians with the core knowledge needed to excel in board exams and manage toxicology-related emergencies effectively.