Explore the future of server-side web frameworks in this thought-provoking conference talk by Django co-creator Adrian Holovaty. Delve into the potential obsolescence of current frameworks and question the necessity of generating HTML from scratch for each page request. Discover how to automate new best practices like Pjax and learn about innovative solutions for multiple content boxes, context-switching, and auto-diffs via Ajax. Examine the benefits of passing HTML instead of structured data, and gain insights into implementing these concepts using Django middleware and template inheritance. Address challenges such as partial titles, nested template logic, and security concerns while considering the implications for developers across various frameworks, including Ruby on Rails.