Explore the functional architectures of human diseases and complex traits in this 37-minute conference talk by Steven Gazal at the Computational Genomics Summer Institute (CGSI) 2023. Delve into the journey from polygenicity to variant function, drawing insights from related papers published in Science and Nature Genetics. Gain a deeper understanding of how genetic variations contribute to complex traits and diseases, and learn about the latest advancements in computational genomics research.