Explore polygenic approaches for testing and refining depression disease models in this 31-minute conference talk from the Computational Genomics Summer Institute (CGSI) 2023. Delve into cutting-edge research on phenotype integration, genetic heterogeneity, and polygenic epistasis in major depressive disorder (MDD). Learn about the differences between MDD symptoms collected using various assessment tools and how these insights can improve genetic studies. Examine methods for identifying genetic heterogeneity within phenotypically defined disease subgroups and models for coordinated polygenic epistasis in complex traits. Gain valuable knowledge on how factorizing polygenic epistasis can enhance prediction and uncover biological pathways in complex traits like depression.