Explore mechano-epigenetics for cell engineering in this 43-minute lecture by Song Li, Chancellor's Professor and chair of UCLA's bioengineering department. Delve into Li's interdisciplinary research on mechanotransduction, cell engineering, and regenerative medicine. Learn about biophysical regulation of epigenetic states, cell differentiation, and reprogramming. Discover how nuclear shape influences histone modifications and how intracellular tension reduction enhances reprogramming efficiency. Examine the effects of mechanical loading on cells and nuclei using a single-cell deformation microfluidic platform. Investigate how nucleus deformation impacts neuronal gene activation, chromatin accessibility, and nuclear lamina structure. Compare biophysical and chemical effects on different cell types and gain insights into the field of mechano-epigenetics for advancing cell engineering techniques.