Explore a 25-minute webinar on functional genomic interrogation of tumor evolution presented by Dr. Kris C. Wood, Associate Professor at Duke University. Delve into two key aspects of cancer biology: context-dependent regulation of survival signaling and functional tumor evolution. Examine vulnerabilities arising during tumor evolution, focusing on the effects of selinexor and AKT activation. Investigate the role of P2RY2 upregulation in AKT activation and its dependence on p110g, p101, and Ras. Analyze the concept of antagonistic pleiotropy in cancer genes and the systematic analysis of the APA PRC2/NSD/MYC AP axis. Discover how PRC2/MYC dysregulation drives evolved BRD4i resistance and how MYC influences BIM-dependent apoptotic priming and BCL-2 inhibitor sensitivity. Gain insights into cutting-edge cancer research and potential therapeutic approaches.