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Intro
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Overview
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Only some of your genealogical ancestors will be your genetic ancestors
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Admixed populations are a combination of multiple sources
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Individual genomes carry signatures of admixture
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Classically admixture has been modelled by considering simpler scenarios
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Implement a mechanistic model of admixture
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Use ancestry proportions from the present to estimate, Z, the number of ancestors from each source population that contributed to genome of an admixed individual
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Implementing the model to improve our understanding of African American history
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Summary of our approach for fitting the model
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Model assumptions
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Estimating the number of genealogical ancestors. that are represented in an African American individual's genome
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Estimating the number of genealogical ancestors that are represented in an African American individual's genome
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Hundreds of African ancestors and tens of European ancestors
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As the number of African ancestors increases the number of European ancestors decreases
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ancestry occurs during the initial epoch
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Number of African and European ancestors varies per generation
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The probability of having an African or European ancestor peaks during the height of the Trans- Atlantic Slave Trade
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Global ancestry can be used to infer the admixture history of admixed individuals
Description:
Explore a conference talk from the Computational Genomics Summer Institute (CGSI) that delves into the number of genealogical ancestors tracing to source groups in admixed populations. Learn about a mechanistic model of admixture and its application to improve understanding of African American history. Discover how ancestry proportions from the present can estimate the number of ancestors from each source population contributing to an admixed individual's genome. Examine the relationship between African and European ancestors in African American genealogy, including how their numbers vary per generation and peak during the Trans-Atlantic Slave Trade. Gain insights into using global ancestry to infer admixture history and understand the complex signatures of sex-biased admixture on the X chromosome.

On the Number of Genealogical Ancestors Tracing to Source Groups in Admixed Populations

Computational Genomics Summer Institute CGSI
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#Science #Biology #Genetics #Population Genetics #Social Sciences #Sociology #Genealogy #Data Science #Bioinformatics #Computational Biology
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Intro