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Intro
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Thyroid Eye Disease: Understanding the Disease & New Treatments Andrea Lora Kossler, MD, FACS
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OUTLINE
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GRAVES DISEASE THE SYSTEMIC COMPONENTS
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THYROID EYE DISEASE (TED)
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AUTOIMMUNE DISEASE
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KEY PLAYER TED: THE ORBITAL FIBROBLAST
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TED PATHOPHYSIOLOGY
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TED IS ASSOCIATED WITH SIGNIFICANT VISION-THREATENING IMPAIRMENTS
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EYELID RETRACTION 911
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DIPLOPIA (DOUBLE VISION) 43-51%
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TED HAS BROAD IMPLICATIONS FOR PATIENTS' LIVES
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MILD TED
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LIMITED WINDOW FOR TREATMENT1-3
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TREATMENT: MULTIDISCIPLINARY APPROACH
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CASE 1: 67 YEAR OLD FEMALE WITH EYE REDNESS, SWELLING, & PAIN X 2 MONTHS
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CURRENT MANAGEMENT OPTIONS FOR TED
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STEROIDS WERE THE PREVIOUS GOLD STANDARD TREATMENT
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MEDICAL THERAPY: ORBITAL RADIATION
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VISION THREATENING TED
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TREATMENT-COMPRESSIVE OPTIC NEUROPATHY
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CASE 2: 45 YO MALE TED, PROPTOSIS OU, DOUBLE VISION, PAIN, SWELLING AND LOSS OF VISION
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BIOLOGIC THERAPY
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TEPROTUMUMAB RESPONSE
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OPTIC (PHASE 3) PROSPECTIVE RANDOMIZED TRIAL
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SURGERY IS CURRENTLY THE MAIN OPTION FOR FIBROTIC TED
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27 FEMALE PROPTOSIS AND LAGOPHTHALMOS
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EYELID CREASE INCISION
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POST OP WEEK 3 SP LATERAL WALL DECOMPRESSION
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CONCLUSION- THYROID EYE DISEASE
Description:
Explore the causes, effects, and latest treatments for Thyroid Eye Disease in this informative lecture by Dr. Andrea Lora Kossler, Assistant Professor of Ophthalmology at Stanford University School of Medicine. Learn about the distressing impact of this condition on patients' appearance and vision, and discover how newly developed treatments can potentially alter the disease's progression. Gain insights into the multidisciplinary approach to managing Thyroid Eye Disease, including medical therapies, orbital radiation, and surgical options. Examine real-world case studies that illustrate the challenges and treatment strategies for various severities of the disease. Understand the role of biologic therapy, particularly teprotumumab, in addressing this autoimmune condition. Delve into the complexities of Graves' Disease, the systemic components involved, and the key players in the disease's pathophysiology. This comprehensive presentation covers everything from mild cases to vision-threatening complications, providing valuable knowledge for healthcare professionals and patients alike. Read more

Thyroid Eye Disease - Understanding the Disease and New Treatments

Stanford University
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