Delve into the complexities of sex, gender, and genomics in this symposium panel discussion organized by the National Human Genome Research Institute. Explore challenges and opportunities for clear communication about these topics, examine trans data storage in big data contexts, and learn about elevating equity in scientific publishing. Join experts from diverse fields as they engage in interdisciplinary conversations aimed at clarifying the multifaceted relationships between sex characteristics, gender, and genomics. Gain insights into the scientific, ethical, and historical contexts surrounding these issues, and participate in a thought-provoking Q&A session. Conclude with closing remarks that synthesize key takeaways from this illuminating discussion on the intersections of biology, social science, and genomics research.