Explore cutting-edge genome editing technologies and their therapeutic applications in this seminar by David R. Liu, a renowned scientist and innovator in the field of genetic engineering. Delve into the development and applications of evolved base editors, prime editors, recombinases, and transposases for targeted gene correction and integration in cells, animals, and patients. Learn about the latest advancements in precision gene editing without double-stranded breaks, including base editing and prime editing, which have already shown clinical benefits in treating various genetic diseases. Gain insights into the integration of chemistry and evolution to illuminate biology and enable next-generation therapeutics, as well as the engineering and in vivo delivery of genome editing proteins. Discover the potential of these technologies in studying and treating genetic diseases, and understand their impact on ongoing clinical trials for conditions such as leukemia, hypercholesterolemia, sickle-cell disease, and beta-thalassemia. Read more