Explore time-dependent diffusion MRI for microstructural mapping of the human brain and tumors in this 50-minute seminar presented by Dr. Dan Wu from Zhejiang University. Delve into the fundamentals of diffusion MRI-based microstructural mapping and learn about the principles of time-dependent diffusion MRI (TDDMRI). Discover preclinical applications and clinical attempts using TDDMRI, including its use in prostate cancer, pediatric glioma, and breast cancer. Gain insights into the development of TDDMRI pulse sequences and current clinical collaborations. Examine methods for improving microstructural fitting, such as q-tspace joint model estimation for time-dependent Kurtosis imaging (tDKI). Conclude with a look at the development of high-gradient systems, including head-only ultra-high gradient systems, and their potential impact on the field.