Explore neuroimaging markers and mechanisms of neurodegeneration in hereditary cerebellar ataxias through this 43-minute lecture by Dr. Ian Harding from Monash University. Delve into two fundamental approaches, longitudinal studies, clinical trials, and histopathology findings. Examine white matter integrity, spatial correlations, and fMRI studies related to cerebellar ataxias. Learn about the Enigma Consortium's work and discover functional and anatomical consequences of these disorders. Gain insights into the current status of research on the central nervous system in hereditary cerebellar ataxias, with a focus on the dentate nucleus. Understand how neuroimaging techniques are advancing our understanding of these neurodegenerative conditions and their potential implications for future clinical interventions.