Explore the fundamentals of microfluidics in this comprehensive lecture by Prof. Terence Kuzma from Pennsylvania State University. Delve into the unique physics of fluids at the microscale, learn about modern manufacturing processes for creating lab-on-a-chip devices, and discover solutions to overcome associated challenges. Gain insights into the fabrication of microfluidic channels through a hands-on experience in a teaching cleanroom, complete with detailed recipes. Examine the simulation of a microfluidic channel designed to separate red blood cells as a practical application. Cover topics such as micro arrays, advantages and disadvantages of microfluidics, electro-osmosis, laminar flow, Reynolds number, Peclet number, mixers, common materials used in microfluidics, and the dimensions of gene chips.