Explore the latest developments in genomic medicine and population screening in this comprehensive conference talk from the National Human Genome Research Institute's 15th Genomic Medicine meeting. Delve into discussions on the current state of population genomic screening in the U.S., barriers and opportunities for expanded screening, impact on clinical practice and outcomes, various genomic screening technologies and costs, and evidence gaps informing future research directions. Learn about pre-testing research focused on provider and patient uptake, testing phase considerations including test recommendations and result types, and follow-up research on intervention uptake and cascade testing. Gain insights from expert presentations and discussions, concluding with a summary of key findings and next steps in the field of genomic medicine and population screening.