Explore the intricacies of McArdle disease, also known as Glycogen Storage Disease type V (GSD-V), in this comprehensive 25-minute video lecture on clinical biochemistry and genetics. Delve into the deficiency of the muscle glycogen phosphorylase enzyme and its impact on glycogen breakdown in muscles. Understand the connection between this enzymatic deficiency and muscle weakness. Gain insights into glycogen metabolism, including glycogenesis (glycogen synthesis) and glycogenolysis (glycogen breakdown). Learn essential information relevant to doctors, nurses, pharmacists, physician assistants, dietitians, and premed students studying metabolism and clinical biochemistry.