Explore the fundamentals of genome-wide association studies (GWAS) and quantitative genomics in this comprehensive lecture by Bruce Walsh. Delve into the genetic architecture of complex traits and learn how to analyze phenotypic variation in relation to underlying genetic factors. Discover the latest approaches to understanding polygenic adaptation and its implications for evolutionary biology. Gain insights into the integration of various adaptive dynamics models, from large changes at few genetic loci to infinitesimal changes across numerous loci. Examine empirical data and quantitative methods for describing different adaptation scenarios. This lecture is part of a broader program on theoretical and empirical approaches to polygenic adaptation, featuring pedagogical lectures, research seminars, and interactive tutorial sessions.