Explore the intricate world of protein folding in confined spaces through this 42-minute physics lecture by Margaret Cheung, Assistant Professor of Physics at the University of Houston. Delve into the complexities of cellular functions, cell composition, and the macromolecular crowding effect. Examine energy landscapes and parallel tempering techniques used to study protein folding. Analyze results focusing on shape parameters, transition states, and denatured states, including the intriguing "pancake" conformation. Compare theoretical findings with experimental data to gain a comprehensive understanding of protein behavior in pores and emulsions.