Explore a comprehensive lecture on the complex interplay between selection, genetic covariances, and network position in predicting gene expression. Delve into the intricate world of polygenic adaptation and its impact on phenotypic variation. Learn how these factors contribute to our understanding of biological evolution and the genetic architecture of traits. Gain insights into the integration of different adaptive dynamics models and their application to empirical data. This talk, presented by Frédéric Guillaume, is part of a broader program on theoretical and empirical approaches to understanding polygenic adaptation, organized by the International Centre for Theoretical Sciences.