Explore the rich history and evolution of the National Human Genome Research Institute's Intramural Research Program through an engaging panel discussion featuring all four scientific directors who have led the program over its 30-year existence. Gain insights into the recruitment processes, leadership styles, and major achievements that shaped the IRP's scientific culture and infrastructure. Discover how the Human Genome Project influenced the program's rapid growth, learn about the challenges faced during budget cuts, and understand the current issues confronting the IRP. This informative conversation, moderated by NHGRI's Communications Director, offers a unique perspective on the institute's journey, complete with personal anecdotes and reflections from the leaders who steered its course.