Dive into the first day of a comprehensive workshop on the genetic architecture of complex human traits, co-sponsored by the National Human Genome Research Institute. Explore cutting-edge research and discussions through a series of presentations and panel discussions. Begin with a welcome address by Carolyn Hutter, followed by an introduction from Alexander Arguello. Gain insights from Aravinda Chakravarti's keynote lecture, setting the stage for in-depth exploration. Delve into Session 1, introduced by Shamil Sunyaev, featuring presentations by Tuuli Lappalainen, Nasa Sinnott-Armstrong, and Francesca Luca. Conclude with a thought-provoking panel discussion led by Barbara Stranger, synthesizing the day's learnings and fostering further dialogue on this crucial area of genomic research.