Explore a panel discussion on modernizing clinical trials through innovative research designs, biomarkers, genetic testing, digital health devices, and artificial intelligence. Delve into strategies for improving efficiency, participant diversity, and technology utilization in the current system. Examine how scientific innovation, data aggregation from electronic health records and wearable devices, and remote access can accelerate enrollment and treatment availability. Learn from experts Alexis Madrigal, Amy Abernethy, and Jonathan Jackson as they discuss the imperative balance between rigor, speed, safety, and public trust in overhauling clinical trials. Gain insights into the impact of COVID-19 on trial processes, the importance of randomization, and the potential of decentralized and virtual trials in advancing medical research and treatment accessibility.