Explore critical global scientific and social challenges requiring international collaboration among physicists in this panel discussion from the 2022 APS Annual Leadership Meeting. Delve into limiting factors such as visas, supply chain constraints, workforce shortfalls, misinformation, research security, political will, and lack of diversity. Gain insights from a distinguished panel of experts moderated by PBS NewsHour's Miles O'Brien, featuring Jonathan Bagger, Omololu Akin-Ojo, E. William Colglazier, William D. Collins, and Cherry A. Murray. Discover potential solutions and strategies for overcoming obstacles to international scientific cooperation in this comprehensive 1 hour and 45 minute session.