Explore a 45-minute conference talk on pathway-specific TNF-mediated metaplasticity in the hippocampus, presented by Cliff Abraham from the University of Otago. Delve into the neurobiology of learning and the timescales involved in associating events separated by varying durations. Examine the biological mechanisms that induce changes in synaptic connections between neurons, despite the disparity between experiential timescales and neural event timescales. Gain insights into molecular, cellular, and circuit-level mechanisms used by the brain to bridge multiple timescales in individual experiences. Discover how this research contributes to understanding associative learning across different timescales, complementing computational approaches with a focus on biological mechanisms. Recorded as part of the Timescales of Plasticity and Underlying Mechanisms conference at the Kavli Institute for Theoretical Physics, this talk offers valuable perspectives on integrating statistical learning across molecular, cellular, circuit, and behavioral-level phenomena. Read more