Explore the evolving landscape of Hepatitis C treatment and management in this informative lecture by Dr. Sammy Saab from UCLA's Digestive Diseases Division. Delve into topics such as decreasing prevalence, increasing hospitalizations, extrahepatic manifestations, and the evolution of therapy for Genotype 1. Discover the properties of direct-acting agents, combination therapies, and the concept of achieving a cure. Examine special populations, resistance-associated variants, and treatment regimens for various genotypes. Learn about monitoring protocols post-treatment and the challenges in improving the HCV test and cure continuum. Gain insights into model-based predictions for the changing burden of Hepatitis C virus infection and its impact on patient health metrics.