Explore the engineering of Casimir-Polder interactions in nanophotonic systems through this conference talk by Kanu Sinha from Arizona State University. Recorded as part of the Quantum and Thermal Electrodynamic Fluctuations in the Presence of Matter conference at the Kavli Institute for Theoretical Physics, delve into the fascinating world of classical and quantum fluctuating electromagnetic fields and their impact on various phenomena in physics, chemistry, and engineering. Discover the latest advancements in Casimir interactions, quantum field fluctuations in heat transfer, and the challenges posed by 2D topological materials and non-reciprocal systems. Gain insights into ongoing research on quantum friction detection and the discrepancies between experimental and theoretical results. Learn how unraveling these puzzles can lead to profound impacts on fundamental science and novel material applications.