Explore high-accuracy wavefunctions using deep-learning-based variational Monte Carlo in this conference talk by Michael Scherbela from the University of Vienna. Delve into a novel architecture for fermionic wavefunctions that achieves superior accuracy at reduced computational costs compared to previous approaches. Discover how this method calculates the most accurate variational ground state energies for atoms and small molecules to date. Examine the impact of physical prior knowledge on accuracy and learn about accelerating VMC-optimization when calculating solutions for multiple molecular geometries. Gain insights into embedding, invariants, envelope orbitals, and backflow factors, as well as their applications in studying potential energy surfaces, with a focus on ethylene as an example.