Explore a comprehensive lecture on diffusion-based distributional modeling in molecular systems. Delve into the realms of conformer generation, blind docking, and protein modeling with MIT's Tommi Jaakkola. Discover innovative approaches to 3D conformer realization, including torsional diffusion and deep learning methods. Examine the concept of blind docking as a generative model and learn about the DiffDock performance with ESM folded structures. Investigate 3D motif scaffolding challenges and solutions, including conditioning via Sequential Monte Carlo. Gain insights into the integration of protein folding and design, and understand the Poisson flow inspired by electrostatics. This 54-minute presentation, part of IPAM's Learning and Emergence in Molecular Systems Workshop, offers a deep dive into cutting-edge techniques in computational biology and molecular modeling.