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Third Bangalore School on Population Genetics and Evolution
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Introduction to the coalescent theory
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Selection and the coalescent
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The ancestral selection graph
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The Moran model
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The biased voter model
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The dual process
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The ancestral selection graph
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The conditional structured coalescent
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Balancing selection
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A peak of polymorphism is expected. .
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Positive directional selection
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Example: maize and teosinte
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Purifying selection
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Why purifying selection may reduce Ne
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Summary
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What is it good for?
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Detecting selection
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Allele frequency distribution
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Polymorphism & divergence
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Haplotype sharing
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Standard approach 80's-90's
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Plants vs flies
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The CCR5-32 AIDS-
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This approach is now dead
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Sample size over time
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You too, Drosophila!
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"It is difficult to get a man to understand something when his salary depends upon his not understanding it.
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Two possible ways out
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Forget about p-values
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Calibrating background models
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But no model fits Arabidopsis...
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Testing for local adaptation
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Field experiments Schmitt et al
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Alleles associated with fitness advantage are local
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Schmitt et al
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"The method has been shown to be robust to demography..."
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"The method has been sh to be robust co
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etched has been
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"No evidence for population structure was found..."
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evidence for ture was found...
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Moral of the story
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I'm not depressed
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Gene trees & species trees
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A. haller
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The pairwise sequentially Markovian coalescent model
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Problem: the ARG is not Markovian...
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"Effective population size" over time ...
Description:
Explore the intricacies of coalescent theory in this 90-minute lecture from the Third Bangalore School on Population Genetics and Evolution. Delve into topics such as selection and coalescent, the ancestral selection graph, and the Moran model. Examine various types of selection, including balancing, positive directional, and purifying selection, and their effects on genetic diversity. Learn about methods for detecting selection, such as allele frequency distribution and haplotype sharing. Discuss the challenges in interpreting genetic data and the importance of robust statistical approaches. Investigate gene trees, species trees, and the pairwise sequentially Markovian coalescent model. Gain insights into the complexities of population genetics and its applications in evolutionary biology.

Introduction to the Coalescent Theory - Lecture 3

International Centre for Theoretical Sciences
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#Science #Biology #Genetics #Population Genetics #Evolutionary Biology #Evolution #Natural Selection #Genetic Drift
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Third Bangalore School on Population Genetics and Evolution