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DATE: 09 December 2019, 16:00 to
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Lecture 1: 9 December 2019, PM
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Lecture 2: 10 December 2019, PM
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Lecture 3: 11 December 2019, PM
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Lecture 4: 12 December 2019, PM
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Active processes in cells and tissues Lecture 2
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Lecture 2 Phase Separation in Active Systems
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Acknowledgements
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Cellular compartments
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Many cell compartments
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Asymmetric cell division
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granule segregation
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granule dynamics
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granule assembly gradient
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Droplet Physics
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Liquid-liquid coexistence
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granules are liquid drops
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Droplet fusion: hydrodynamics
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In vitro droplet formation
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Thermodynamics of phase coexistence
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Droplet coexistence
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Temperature dependence
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Protein gradient drives granule segregation
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Position dependent phase separation
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Droplet growth and shrinkage
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Ostwald ripening
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Cellular matter is active
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Droplet with chemical reactions
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Detailed balance
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Passive chemical droplets
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Chemically active droplets
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Steady state of active droplets
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Dynamics of active droplets
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Physics of centrosomes
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Centrosome dynamics
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Centrosome assembly
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Chemical transition
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Centrosome: active droplet
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Two growth scenarios
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Nucleation by active centrioles
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Theory- Experiment
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Suppression of Ostwald ripening by active core
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Dynamics of two coexisting autocatalytic droplets
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Symmetric and asymmetric centrosome growth
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Centriole positioning
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RNA-protein assemblies organize chemistry in space
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Coacervates
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Active droplets as simple models for photocells
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Division of active droplets
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Growth-division cycles
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Simple model for photocells
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Conclusions
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Q&A
Description:
Explore a comprehensive lecture on active processes in cells and tissues, focusing on phase separation in active systems. Delve into the physics of cellular compartments, droplet formation, and granule dynamics. Examine the thermodynamics of phase coexistence, protein gradients driving granule segregation, and the behavior of chemically active droplets. Investigate centrosome dynamics, RNA-protein assemblies, and the potential of active droplets as models for photocells. Gain insights into growth-division cycles and the organization of chemistry in space within living systems. This lecture, part of the ICTP-ICTS Winter School on Quantitative Systems Biology, offers a deep dive into the complex and dynamic nature of living matter, exploring how spatial patterns and morphologies emerge at cellular and multicellular scales.

Active Processes in Cells and Tissues - Phase Separation in Active Systems - Lecture 2

International Centre for Theoretical Sciences
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