Explore approaches for analyzing the geometry of molecular conformations in cryo-electron microscopy (cryo-EM) in this 43-minute conference talk by Roy Lederman from Yale University Applied Mathematics. Delivered at IPAM's Cryo-Electron Microscopy and Beyond Workshop, the presentation delves into the unique capabilities of cryo-EM in studying mixtures of molecular conformations. Learn about the success of algorithms in analyzing distinct conformations and the emerging approaches for tackling more complex conformational heterogeneity. Discover the challenges that arise in this field and gain insights into the potential of cryo-EM for advancing our understanding of molecular structures beyond traditional methods like x-ray crystallography and NMR.