Explore the critical issue of antibiotic resistance in this comprehensive 31-minute lecture. Delve into the mechanisms behind antibiotic resistance, understand the principles of susceptibility testing including the Minimum Inhibitory Concentration (MIC), and learn how to interpret antibiotic susceptibility reports. Examine various testing methods such as broth microdilution and disk diffusion, and gain insights into specific cases like inducible clindamycin resistance in Staphylococcus aureus. Investigate the major factors contributing to the global spread of antibiotic resistance, including over-prescription practices and the link between antibiotic use and the emergence of resistant strains. This lecture provides essential knowledge for healthcare professionals and students in understanding the challenges and implications of antibiotic resistance in modern medicine.