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Stochastic models of population dynamics: Wright-Fisher and Moran models; fixation; diffusion theory Lecture - 1
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Statistical Physics of Biological Evolution
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Natural selection
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The atoms of heredity
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The modern synthesis in evolutionary theory
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Experimental evolution
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Richard Lenski's long-term evolution experiment
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Ability to exploit citrate evolved after 31,500 generations
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Clonal interference
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Outline of lectures
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Wright-Fisher model
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An empirical fitness landscape
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Evolutionary trajectories on the A. nigher landscape
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Ancemipinical fitness landscape A nigher landscape
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Suggested reading available on BSSP web page
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I. Stochastic models of population genetics: Wright -Fisher model
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Model resource competition
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Serial dilution experiment
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Genetic drift
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Heterozygosity
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Exercise
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Markov chain has absorbing states n=0, n=N
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Selection: Fitness WA, WB
Description:
Explore the fundamental concepts of biological evolution through statistical physics in this comprehensive lecture. Delve into stochastic models of population dynamics, focusing on Wright-Fisher and Moran models, fixation, and diffusion theory. Examine natural selection, the modern synthesis in evolutionary theory, and experimental evolution, including Richard Lenski's long-term experiment. Investigate concepts like clonal interference, genetic drift, and fitness landscapes. Learn about the Wright-Fisher model, resource competition, and serial dilution experiments. Analyze heterozygosity, Markov chains with absorbing states, and the role of fitness in selection. Gain insights into the statistical physics approach to understanding evolutionary processes through theoretical frameworks and real-world examples.

Statistical Physics of Biological Evolution by Joachim Krug

International Centre for Theoretical Sciences
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