Explore the complexities of treating refractory autoimmune hepatitis in this comprehensive lecture from the 10th Annual UCLA-Mellinkoff Gastroenterology and Hepatology Symposium. Delve into epidemiology, prevalence, and demographics before examining presentation, subclassifications, and diagnostic criteria, including the IAIHG Simplified Scoring System. Learn about therapeutic algorithms, induction therapy, and how to address suboptimal responses. Understand treatment duration, maintenance therapy, and strategies for difficult-to-treat patients. Discuss drug intolerance, side effects, and the challenges of treatment withdrawal and relapse. Gain valuable insights from Dr. Steven-Huy B. Han's expertise in managing this complex autoimmune liver disease.