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1
Introduction
2
Objectives
3
The Immune System
4
The Plasma Cell
5
The M Protein
6
The Spectrum of Disease
7
The Crab Criteria
8
Treatment
9
Response
10
remission
11
response rates
12
complete response
13
Minimal residual disease
14
Storm Trial
15
Venetoclax
16
Immunotherapy
17
Targets
18
BCMA
19
BLEN Rep
20
CAR T Cells
21
CAR T Cells Side Effects
22
Lymphodepletion
23
Iacel
24
Karma 3 Trial
25
Karma 4 Trial
26
Clinical Trial Summary
27
Can We Design a Better CarT Cell
28
Clinical Trials
29
Climb to Cure
30
Thank you
31
Questions
Description:
Explore current and emerging treatments for multiple myeloma in this informative community lecture featuring UCLA hematologist and oncologist Dr. Sarah M. Larson. Moderated by Leila Evangelista from the Leukemia & Lymphoma Society, the talk covers a wide range of topics including the immune system, plasma cells, M protein, disease spectrum, and CRAB criteria. Delve into various treatment approaches, response rates, and the concept of minimal residual disease. Learn about cutting-edge therapies such as Venetoclax, immunotherapy targeting BCMA and BLEN, and CAR T-cell treatments, including their side effects and ongoing clinical trials. Gain insights into the latest research, including the Storm, Karma 3, and Karma 4 trials, and discover efforts to design more effective CAR T-cells. The lecture concludes with information on clinical trials and the Climb to Cure initiative, followed by a Q&A session.

Novel Therapies for Multiple Myeloma - Closer to a Cure Community Lecture Series

University of California, Los Angeles
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