Explore the world of vaccines in this comprehensive lecture presented by Professor Peter Openshaw, an expert in Experimental Medicine at Imperial College London. Delve into the intricacies of COVID-19, understanding its nature and the body's B cell response. Examine various vaccine approaches, including modern technologies and specific vaccines like Oxford-AstraZeneca, Moderna, and Chadox. Learn about reactogenicity, the Vaccine Task Force, and investment strategies. Discuss crucial topics such as vaccination groups, mutations, variants, and vaccine doubts. Investigate prospects for COVID-19 vaccines, potential failures, and strategies for measuring immune responses. Explore long-term effects, infant vaccination rates, and the impact of anti-vaccine movements. Gain insights into mucosal vaccines, escape mutants, and mixed vaccine approaches. Understand why certain variants are more transmissible and how vaccines might affect immunosuppressed individuals.