Explore the fundamental role of water in protein folding and life in this 45-minute lecture by Sylvia McLain at The Royal Institution. Delve into the unique properties of water as a universal solvent and its indispensable role in biological processes. Learn about hydrophobic effect theory, diffraction techniques, particle accelerators, and isotope substitution used to study protein-water interactions. Discover how crystallography, computer models, and molecular studies of substances like methanol and cocaine contribute to our understanding of water's function in biological systems. Gain insights into the sequence of events in protein folding and the concept of water as a "glue" in biological processes. Despite initial audio issues, this comprehensive talk provides a deep dive into the physics of life and the crucial interplay between water and proteins.