Explore the fascinating world of intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) in gene transcription through this 69-minute seminar presented by H. Jane Dyson. Delve into detailed biophysical studies focusing on the disordered domains of two crucial transcription factors, CREB and p53, while learning how their interactions and post-translational modifications contribute to proper transcription functioning. Gain valuable insights into how disorder plays a fundamental role in biological processes, particularly in the context of chemical biology and gene regulation.