Learn about groundbreaking genetic research in cardiovascular medicine through this Yale Cardiovascular Medicine Grand Rounds lecture that explores the complex relationship between genetics and heart disease. Delve into detailed case presentations examining metabolic syndrome, rare genetic variants, and high-risk populations. Explore the connections between fatty liver disease, insulin secretion, and LDL receptor function while understanding the role of common variants and histone modifiers in cardiovascular health. Examine cutting-edge mouse studies investigating renin's role in hypertension and the genetic factors influencing abdominal aneurysms. Gain valuable insights into visceral obesity and its genetic implications for cardiovascular disease, combining clinical observations with molecular research to understand both progress made and challenges ahead in genetic approaches to treating cardiovascular diseases.