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Organic Chemistry in Biology and Drug Development

Lecture 1 : A brief introduction to Molecules of Life

Lecture 2 : Biological Macro molecules and Small molecules: Importance and functions

Lecture 3 : Amino Acids: The building block of proteins

Lecture 4 : Amino acids: separation and detection, Electrophoresis and Ninhydrin reaction

Lecture 5 : Method of determination of Amino acid sequence: primary structure of polypeptide/protein

Lecture 6 : Selective peptide bond cleavage: Enzymatic and Non-enzymatic methods

Lecture 7 : Peptide synthesis: Protecting groups for amine and carboxyl functionality

Lecture 8 : Peptide synthesis (continued): Protection, coupling and deprotection methods

Lecture 9 : Recent development of coupling agents;

Lecture 10 : Hierarchial structure of proteins: Secondary, tertiary and quaternary structure

Lecture 11 : Ramachandran plot and protein purification techniques

Lecture 12 : Protein Purification Techniques (Contd.)

Lecture 13 : Introduction to Enzymes and its kinetics

Lecture 14 : Enzyme catalysed reactions and introduction to catalytic activity of proteases

Lecture 15 : Enzyme Kinetics (Contd.)

Lecture 16 : Concept of Enzyme Inhibition

Lecture 17 : Concept of Enzyme Inhibition (Contd.)

Lecture 18 : Problems on Enzyme Kinetics and Enzyme Inhibition

Lecture 19 : Synthetic Biology

Lecture 20 : Synthetic Biology (Contd.)

Lecture 21 : Synthetic Biology (Contd.)

Lecture 22 : Nucleic Acid

Lecture 23 : Nucleic Acid (Contd.)

Lecture 24 : DNA sequencing method

Lecture 25 : DNA sequencing method (Contd.)

Lecture 26 : DNA sequencing method (Contd.)

Lecture 27 : Synthesis of oligonucleotide

Lecture 28 : Central dogma: DNA replication, transcription and translation

Lecture 29 : Central dogma: DNA replication, transcription and translation (Contd.)

Lecture 30 : Central dogma: DNA replication, transcription and translation (Contd.)

Lecture 31 : Central dogma: DNA replication, transcription and translation ((Contd.)

Lecture 32 : Central dogma: DNA replication, transcription and translation (Contd.)

Lecture 33 : Molecular Biology

Lecture 34 : Molecular Biology (Contd.)

Lecture 35 : Chemistry of cofactors/coenzymes

Lecture 36 : Chemistry of cofactors/coenzymes (Contd.)

Lecture 37 : Chemistry of cofactors/coenzymes (Contd.)

Lecture 38 : Chemistry of cofactors/coenzymes (Contd.)

Lecture 39 : Chemistry of cofactors/coenzymes (Contd.)

Lecture 40 : Chemistry of cofactors/coenzymes (Contd.)

Lecture-41: " Introduction to Drug Discovery Process"

Lecture-42: " Fundamental Principles of Drug Development Process"

Lecture-43: " Combinatorial chemistry"

Lecture-44: "Neurotransmitters"

Lecture-45: " Catechol amine based and GABA neurotransmitters"

Lecture-46: " Hypertension: humoral mechanism and renin/angiotensin system"

Lecture-47: " Inhibitor design of angiotensin converting enzyme"

Lecture 48: Antimicrobial drugs

Lecture 49: Chemistry of penicillins

Lecture 50: Resistance to beta-lactam antibiotics

Lecture 51: Mechanistic studies of beta-lactamase

Lecture 52: Non beta-lactam antibiotics

Lecture 53: Mechanistic enzymology of Isopenicillin N synthase

Lecture-54 : Polyketide Biosynthesis

Lecture 55 : Biosynthesis of macrolide polyketides and introduction to virus

Lecture 56 : Anti-viral drugs

Lecture-57 : Cancer and Chemotherapy

Lecture-58 : Anti-cancer drugs (contd)

Lecture 59 : Aromatase inhibition and Anti-ulcer drugs

Lecture-60 : Cholesterol lowering agents

Lecture 61 : Cholesterol Biosynthesis

Lecture-62 : Pharmakinetics and pharmadynamics

Lecture-63 : QSAR principles

Description:

COURSE OUTLINE: In the biosphere, the chemistry must be considered in the context of the cell, or an organ, or even a whole organism. That makes mimicking of biological processes to be extremely challenging as the reaction needs to be performed with perfect orthogonality to other functional entities present in a biological system. Today, with the advancement of various spectroscopic and molecular biology techniques and with a better understanding of chemical principles, functions of various bio molecules have been unravelled which has paved the way for development of newer drugs. The present course is an attempt to bridge the gap in our understanding of biological systems and processes at the molecular and functional level. The course first introduces the various kinds of bio molecules, macro to medium size to small, their structures and functions followed by molecular engineering to manipulate their activity and biosynthesis. That creates a perfect platform for the next module on drug design and discovery. Read more

Organic Chemistry in Biology and Drug Development

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#Science #Chemistry #Organic Chemistry #Biology #Health & Medicine #Health Care #Pharmacology

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